Tell your doctor immediately if any of these rare but serious side effects occur: easy bruising/bleeding, persistent heartburn, shaking, mask-like facial expressions, muscle spasms, severe stomach/abdominal pain, decreased sexual ability/desire, enlarged/painful breasts.
Gabapentin produced greater improvements than amitriptyline in pain and paresthesia associated with diabetic neuropathy. Additionally, gabapentin was better tolerated than amitriptyline. Further controlled trials are needed to confirm these preliminary results.
Researchers tested amitriptyline, the TCA most commonly used to treat IC, in a randomized, prospective, placebo-controlled trial for IC. The researchers found that symptom scores dropped, and that pain and urinary urgency improved significantly in the amitriptyline group compared with the placebo group.
If you suddenly stop taking amitriptyline, you may experience withdrawal symptoms such as nausea, headache, and lack of energy. Your doctor will probably decrease your dose gradually.
It works on two chemicals, noradrenaline and serotonin, that are found in nerves. When amitriptyline is used to treat nerve pain, it lowers the pain signals to the brain. This helps to reduce the level of pain you experience, which can enable you to get back to your daily activities and have a better quality of life.
Amitriptyline, a frequently prescribed tricyclic antidepressant, is reported to produce an age-related impairment in anterograde memory. However, the locus of this adverse effect has never been described within the context of contemporary learning and memory theory.
But it usually takes a week or so for pain to begin to wear off. It can take between 4 and 6 weeks before you feel the full benefits. Do not stop taking amitriptyline after 1 to 2 weeks just because you feel it’s not helping your symptoms.
Small studies have shown that low dose tricyclic antidepressants (TCAs), such as amitriptyline, may be effective in treating IBS. Amitriptyline may help with IBS because it relieves pain and changes bowel activity, rather than because it affects mood.
Like all antidepressants, experts recommend against taking a tricyclic medication without a mood stabilizer (such as lithium or divalproex) in bipolar I disorder, in order to minimize the chance of inducing mania symptoms. Tricyclic antidepressants include: Elavil (amitriptyline)
Amitriptyline (Elavil) and nortriptyline (Pamelor) are an older type of antidepressant known as tricyclic antidepressants. They are used to treat depression and anxiety, and they are used off-label for chronic pain and to prevent migraines. They too can cause drowsiness and fatigue, among other side effects.